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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: RET All Species: 9.09
Human Site: Y905 Identified Species: 18.18
UniProt: P07949 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P07949 NP_065681.1 1114 124319 Y905 D V Y E E D S Y V K R S Q G R
Chimpanzee Pan troglodytes XP_001171246 813 90715 H612 L A S K K C I H R D L A A R N
Rhesus Macaque Macaca mulatta XP_001090823 731 81824 H530 L A S K K C I H R D L A A R N
Dog Lupus familis XP_543915 1108 124018 Y899 D V Y E E D S Y V K R S K G R
Cat Felis silvestris
Mouse Mus musculus P35546 1115 123855 Y906 D V Y E E D S Y V K K S K G R
Rat Rattus norvegicus Q04589 822 91806 H621 L A S K K C I H R D L A A R N
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001507715 665 75620 I464 V K R S K G R I P V K W M A I
Chicken Gallus gallus P18461 823 92281 Q622 G M E Y L A S Q K C I H R D L
Frog Xenopus laevis Q03364 813 91322 C612 E Y L A S Q K C I H R D L A A
Zebra Danio Brachydanio rerio Q8JG38 817 91370 Q616 G M E Y L A S Q K C I H R D L
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q09147 1052 117795 G851 F A F Q I A R G M E Y L A S R
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus Q26614 972 110463 F771 Q V A R G M D F L A S K K C I
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 28.4 27.9 86.4 N.A. 83.4 28.9 N.A. 43 27.5 28.1 27.7 N.A. 23.6 N.A. N.A. 24
Protein Similarity: 100 42.2 41.5 92 N.A. 90.2 43 N.A. 50.5 43.5 42.3 42 N.A. 37.7 N.A. N.A. 41.2
P-Site Identity: 100 0 0 93.3 N.A. 86.6 0 N.A. 0 6.6 6.6 6.6 N.A. 6.6 N.A. N.A. 6.6
P-Site Similarity: 100 26.6 26.6 100 N.A. 100 26.6 N.A. 13.3 20 20 20 N.A. 33.3 N.A. N.A. 26.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 34 9 9 0 25 0 0 0 9 0 25 34 17 9 % A
% Cys: 0 0 0 0 0 25 0 9 0 17 0 0 0 9 0 % C
% Asp: 25 0 0 0 0 25 9 0 0 25 0 9 0 17 0 % D
% Glu: 9 0 17 25 25 0 0 0 0 9 0 0 0 0 0 % E
% Phe: 9 0 9 0 0 0 0 9 0 0 0 0 0 0 0 % F
% Gly: 17 0 0 0 9 9 0 9 0 0 0 0 0 25 0 % G
% His: 0 0 0 0 0 0 0 25 0 9 0 17 0 0 0 % H
% Ile: 0 0 0 0 9 0 25 9 9 0 17 0 0 0 17 % I
% Lys: 0 9 0 25 34 0 9 0 17 25 17 9 25 0 0 % K
% Leu: 25 0 9 0 17 0 0 0 9 0 25 9 9 0 17 % L
% Met: 0 17 0 0 0 9 0 0 9 0 0 0 9 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 25 % N
% Pro: 0 0 0 0 0 0 0 0 9 0 0 0 0 0 0 % P
% Gln: 9 0 0 9 0 9 0 17 0 0 0 0 9 0 0 % Q
% Arg: 0 0 9 9 0 0 17 0 25 0 25 0 17 25 34 % R
% Ser: 0 0 25 9 9 0 42 0 0 0 9 25 0 9 0 % S
% Thr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % T
% Val: 9 34 0 0 0 0 0 0 25 9 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 9 0 0 0 % W
% Tyr: 0 9 25 17 0 0 0 25 0 0 9 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _